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However, regular users sometimes report ongoing mild gum irritation, and in rare cases, gum recession or uneven colour along the gum line

The study also found that nicotine produced these negative effects by stimulating the ion channel transient receptor potential ankyrin 1 (TRPA1)

Despite their desire to leave and the negative consequences of tobacco use, individuals struggle to maintain tobacco abstinence and find themselves relapsing into tobacco use

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Unlike smoking, chewing tobacco delivers a constant dose of nicotine into the blood stream