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Yes, but they are often less intense and less frequent than with standard dosing

It is thought to promote weight loss through various mechanisms, including effects on the central nervous system, metabolic changes, and suppressing appetite

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GLP-1 drugs have obviously been all the rage for weight loss, and there has been some off-label use of them to treat liver disease like MASH, but in the Phase III ESSENCE trial, after 72 weeks, 63% of patients on Wegovy saw their steatohepatitis resolved without any worsening of fibrosis, compared to just 34% with placebo

The results of the subgroup analysis in this study were similar

The daily injection requirement deters some patients but provides steady levels without the peaks and troughs of weekly dosing