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References 1 American Diabetes Association Professional Practice Committee

This gradual escalation is based on clinical trials showing that slower progression improves tolerability and allows identification of your optimal dose

In the published analyses, rates of reflux were low and did not show a significant difference between treatment and placebo groups

This standardization makes it easier to measure small volumes accurately, which is critical when your therapeutic dose might be just 0.25mg or 0.5mg of actual medication

Hepatology 2000