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Schroeder SA, & Morris CD

This agent, which was originally marketed as an antidepressant, is hypothesized to promote smoking cessation by inhibiting the reuptake of dopamine and norepinephrine in the central nervous system 54 and may function as a nicotinic acetylcholine-receptor antagonist

Percentage of patients aged 12 years and older who were identified as a tobacco user during the measurement period who received tobacco cessation intervention during the measurement period or in the six months prior to the measurement period Criterion 3

[27] [4] In 2010 more than 200 000 people died from coronary heart disease due to smokeless tobacco use

Carcinogenesis 23 , 19792004 (2002)