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In contrast, nicotine replacement therapies (e.g., patch, gum, lozenge) and some prescription medications (i.e., varenicline, bupropion) have been evaluated by the FDA and found to be safe and effective at helping people quit smoking
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Following the discovery that nicotine alters the expression of the PRM1 and PRM2 genes, further studies were conducted to investigate whether various nicotine products, such as smoking and hookah, had a different impact on the expression of these protamines [86, 96, 97, 104, 105, 106]
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The smokeless tobacco industry sold a whopping $4.98 billion in 2022, which only validates the seriousness of the addiction in the United States
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