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However, it is important to point out that IF is species-specific and these vitamin B12+IF supplements have not been tested in clinical studies to support their use

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Low red blood cell counts (anemia) due to vitamin B12 deficiency

PMCID: PMC7489598

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This process apparently starts when the VEGF protein, which is considered to be secreted by oxygen-deprived cells during a hypoxic response, and may bind to VEGF receptors on the surface of endothelial cells