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Meta-analyses were performed to estimate the pooled RRs and 95% confidence intervals (CIs) based on both fixed- and random-effects models

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Other common nicotine withdrawal symptoms include nicotine cravings, depression, restlessness, irritability, headaches, trouble concentrating, body or mental fatigue, increased appetite, and insomnia

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Adjustment and Conditioning Once blending is complete, the tobacco leaves are moistened to achieve the desired texture for chewing

20 The second model is known as the 5 Rs. These are: relevance to the patient