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demonstrated that Sprague-Dawley rats exposed in utero to cigarette smoke extract, exhibited significantly reduced glomerular volume and podocyte number suggesting that prenatal exposure to nicotine and its metabolites may negatively impact glomerular development [8]
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The complexity of flavour chemistry means that predicting these changes is difficult without laboratory analysis, and degrading flavour concentrates can alter both taste and vapour production over time
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doi: 10.1016/j.ypmed.2021.106529
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Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
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