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Semaglutide should not be used if you or any family members have had medullary thyroid carcinoma (MTC), or if you have a condition known as Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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But there are a few risks to consider, including: Some people form antibodies to GLP-1 agonists, particularly with exenatide

Bariatric procedures such as Roux-en-Y gastric bypass and sleeve gastrectomy alter gastric volume, intestinal transit, nutrient absorption, and hormone signaling

First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization