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(Although multiple sclerosis (MS) is classically an autoimmune inflammatory demyelinating disease rather than a primary proteinopathy, we include it here due to overlapping chronic CNS injury and immune dysregulation influenced by the microbiome.) For each disease, specific microbial taxa, metabolites, and pathways implicated in pathogenesis are discussed

Chem Biol Interact 138:7783

The Closest Human Evidence and It Was Negative There is no human Dihexa trial, but the same HGF/c-Met drug program did reach human testing through Athira Pharma's fosgonimeton (ATH-1017)

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The authors findings were likely due to the small rises in NO observed in these studies, as they were not significantly different to the placebo (CM: 15.3 1.1

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