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A product with low abuse liability likely will not be adopted or used extensively and may not encourage existing smokers to switch from using high-harm cigarettes to lower-harm THPs, and some degree of abuse liability of nicotine products has been proposed to support overall population tobacco harm reduction 44,45

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As of 2021, nearly 12 of every 100 U.S

Similarly, e-cigarette exposure disrupted protein membrane expression and induced a glycolytic, proinflammatory state in macrophages [33]

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