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The statistical package SPSS version 24 was used to perform the analysis

PNE was found to alter norepinephrine transporter (NET) binding expression in both sexes and Catechol-O-methyl transferase (COMT)-dependent dopamine turnover in males

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Second, the pathophysiologic mechanisms underlying the cardiovascular adverse effect are not fully understood, and thus, studies to address these issues are not only warranted but also critical at this point