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Animal models of abuse and addiction tend to focus on the ability of the drugs to directly control the animals behavior and to induce a rewarding effect that is not dependent on preexisting conditions [161]

These riskoutcome pairs are automatically assigned a zero-star rating, and the BPRF and ROS are not computed (Extended Data Fig

Attempt was also made to search grey literature through unpublished articles and manual searching of non-indexed journals, but no articles were retrieved

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