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This is due to the fact that the model-based estimators borrow strength from similar domains to overcome the lack of observations in smaller states/territories and increase the effective sample size to obtain better accuracy in the estimated trends

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61,103 However, at higher concentrations, uric acid reduces NO bioavailability, impairs eNOS function, reduces NO production, and further exacerbates endothelial cell dysfunction

Firewater , p.57

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The natural history of hyperuricemia among asymptomatic relatives of patients with gout