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In COPD, chronic oxidative stress and inflammation trigger premature epithelial cell senescence, which contributes to loss of epithelial integrity and airway inflammation and remodelling

Clinicians should subsequently use the 5 As tobacco and nicotine cessation strategy, which includes 5 tasks: Ask, Advise, Assess, Assist, and Arrange (Figure 1)

Im more worried about chronic, heavy exposure: people who are using marijuana every day, multiple times a day

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One neural system that appears to be most affected by cocaine originates in a region, located deep within the brain, called the ventral tegmental area (VTA)