Accordingly, the World Health Organization classifies G6PD-d based on the level of residual G6PD activity, with severe deficiency (Class I) causing chronic nonspherocytic hemolytic anemia and the least severe deficiency (Class IV) with little-to-no appreciable phenotype 8,11
Mechanism of action Acitretin exerts its effects by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), leading to gene transcription changes that mediate its anti-proliferative and anti-inflammatory properties
Table 1 Types, dietary sources and mechanism of action of antioxidants
H tr tng cng ni tit t n, gip ci thin sinh l n
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The resulting GSH or homoglutathione (-L-glutamyl-L-cysteinyl--alanine) conjugates were usually much less toxic and more water-soluble than the original xenobiotics (Brown and Neighbors, 1) (Bartling et al., 2002