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Very high HbA1c at diagnosis (above 10 percent) with hyperglycemic symptoms

For most people, gastroparesis symptoms improve after reducing the medication dose or stopping it entirely

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If symptoms from such a hernia are severe, for example, if chronic acid reflux threatens to severely injure the esophagus or is causing Barrett's esophagus, surgery is sometimes recommended

This dose-tolerability relationship provides useful guidance for clinical protocol development