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Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols

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Although it is not approved for human use by any major regulatory body, interest in NNMT inhibition as a research target has driven study of 5-Amino-1MQ in metabolic models

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Accumulation of ATMs during obesity, particularly of pro-inflammatory ATMs, contributes to inflammation and insulin resistance of adipose tissue and was also found to be regulated by NF-B [119]