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Phase I reactions (primarily oxidation, reduction, and hydrolysis) structurally modify the parent compound but frequently generate reactive intermediates that can be more cytotoxic than the original molecules

10.1016/j.exer.2022.109015 73 HuangQ.ChenH.YinK.ShenY.LinK.GuoX.et al (2022e)

Yes, and this comes up in my practice regularly

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Conversely, when crizotinib was combined with radiation therapy, inhibition of c-MET appeared to reduce radiosensitivity in vitro as measured by colony forming assay and in vivo using a mouse model [112]