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Some of the roles of saliva in the mouth are: lubrication, dilution of sugars, antimicrobial and cleansing activity, aiding in tissue repair, and remineralization of enamel with calcium and phosphates

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The 2010 report, which covered the extensive advances in research on nicotine since the 1988 report (USDHHS 2010), reconfirmed nicotines key role in causing addiction and concluded that genetic variations in responses to this drug contribute to determining patterns of smoking behavior and cessation

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