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Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk

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Here we show, by comparing paired sputum and blood samples from smoking and non-smoking patients with asthma, that smoking associates with significantly higher frequencies of pro-inflammatory, natural-cytotoxicity-receptor-non-expressing type 3 innate lymphoid cells (ILC3) in the sputum and memory-like, CD45RO-expressing ILC3s in the blood

These programs have been discontinued in the wake of health issues and smoking advertising bans throughout most of Europe and the USA