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FIGURE 3 3.3 Nitazoxanide reduced inflammation in rats with MTX-hepatotoxicity A profound hepatic inflammation was observed in the MTX group, as demonstrated by significant augmentation in hepatic TNF-, IL-1, and IL-6 versus the CTRL group (Figures 4AC)

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Quinn, C

In order to investigate the effect of p21 on hTERT expression, experiments with T47-D cells by p21 overexpression leads to suppression of hTERT expression

Although it has protective antioxidant functions, its surge may also alter copper kinetics, potentially increasing the delivery of redox-active copper to tissues or disrupting its cellular utilization, thereby paradoxically exacerbating copper-mediated toxicity in cardiomyocytes [177]

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