This led to the assumption that the primary receptors mediating weight loss for this target class were AMYRs, yet, dual agonists are reported to have higher efficacy than AMYR selective agonists 2,10,11,12
- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)
Available from: Cited 4 Nov 2025
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