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Nat Commun 13(1):6543 Jiang S et al (2014) M1 muscarinic acetylcholine receptor in Alzheimers disease

While 24 hr acute exposure to adults did not alter a-wave responses (Fig

Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks

Protein homeostasis is a dynamic balance between protein synthesis and protein degradation, which is critical for maintaining healthy cell functions