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The REWIND study highlighted dulaglutides role in both primary and secondary CV prevention, making it the first Food And Drug Admininstration (FDA)-approved GLP-1RA for reducing MACE in T2DM patients [97]

The SELECT trial builds on these results, showing that once-weekly semaglutide resulted in a 20% reduction in the primary composite endpoint of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with pre-existing cardiovascular disease and BMI 27kg/m 2

GLP-1 agonists have been shown to reduce oxidative stress in diverse preclinical studies

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