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13(6 Pt 2):116S-128S

Patients receiving the placebo showed no improvement

Acetaminophen undergoes detoxification in the liver

Our findings provide a basis for stratifying VRK2-aberrant patients for metabolism-targeted therapies

GGT1 overexpression enhanced SLC7A11 and GPX4 expression while suppressing ACSL4, thereby reducing lipid peroxidation, mitigating oxidative stress, and alleviating tubular injury, whereas co-silencing GCLC attenuated these protective effects