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(Supplementary Figs 2a,b and 3)

d-Carnitine feeding also induced hepatic inflammation, oxidative stress and apoptosis

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That first step is a tolerance dose , not a treatment dose

Conclusions Results of this study indicated that, in contrast to livestock mammals and poultry where creatine synthesis requires the interorgan cooperation of the kidneys and liver but is absent from skeletal muscle, creatine synthesis occurred primarily in skeletal muscles from Phase-I and Phase-II HSB

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