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Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction

Preclinical and early clinical investigations suggest that GLP-1RAs modulate neurobiological pathways underlying addictive behaviors, thereby potentially reducing substance craving and use while simultaneously addressing comorbid conditions

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For intermediate-stage disease, locoregional therapies are primarily recommended although systemic therapies may be preferred for patients with large intrahepatic tumor burden

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