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It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC

Methods 15 , 10531058 (2018)

Consider fiber supplements like psyllium husk or glucomannan if you have trouble getting enough fiber from your food

Horn said the wide range of cardiometabolic improvements observed in the trial was exciting

Meaningful weight loss builds from weeks four to twelve

If side effects are manageable and results are progressing at a moderate dose, there is no requirement to keep increasing