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GLUT4 is considered a master regulator of glucose metabolism

IGF-1 LR3 is a recombinant analog of human IGF-1 comprised of the complete IGF-1 sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension

This reduces the risk of hypoglycemia , a common concern with diabetes medications

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The patients who see the most complete results are those who address multiple systems simultaneously, because GH decline does not happen in isolation and neither does the recovery from it