mixing semaglutide and tirzepatide CONS: ⚠️ Gastrointestinal side effects: Nausea, vomiting, diarrhea, constipation affect approximately 50-60% of patients, especially during initial treatment. ⚠️ Muscle loss: Up to 39% of weight lost may come from lean Managing Nausea on Semaglutide: Evidence-Based

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Tirzepatide (MOUNJARO) is a once-weekly subcutaneous injectable agent first authorized for T2DM and later extended to the management of obesity or overweight with at least one weight-related comorbidity, thereby aligning its therapeutic scope with subcutaneous liraglutide and semaglutide [34,35,36]

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