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In contrast to the UGT1A subfamily, the members of the gene subfamily contain a different set of exons (Tukey & Strassburg, 2000)

Histones embedded in NETs, particularly H3 and H4, exert direct cytotoxicity on ECs, triggering membrane damage, oxidative stress, and attenuation of NO bioavailabilitya key mediator of endothelial vasodilatory and antithrombotic capacity [79]

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The aberrant activation of the SCAP-SREBP2 axis promotes HMGCR-mediated cholesterol synthesis and positively correlates with DAS28 score (5860)

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