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Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study

That said, the components, the vitamins themselves, are well studied, and compounders must adhere to strict quality standards

Another study showed that pregnant womens exposure to extremely high doses of vitamin B12 could lead to the risk of autism spectrum disorder in an unborn child

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Because B12 is water-soluble, your body uses what it needs and passes most of the excess, and there is no established upper intake limit because harmful effects from high intake have not been well documented