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Vitamin Supplementation Reduces Blood Homocysteine Levels: A Controlled Trial in Patients with Venous Thrombosis and Healthy Volunteers. Arteriosclerosis, Thrombosis, and Vascular Biology, vol

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However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise

Rodrigues ML, Signor A, Neu DH

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In some cases, its presence can affect the stability or bioactivity of the peptide