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Peptides with sequences rich in hydrophobic residues, or those with a high proportion of basic amino acids (lysine, arginine, histidine) that require protonation for charge-mediated aqueous solubilisation, typically reconstitute cleanly and completely in 0.1% acetic acid water whereas the same peptides may form aggregates, gels, or turbid suspensions when reconstitution with neutral sterile water or bacteriostatic water is attempted first

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For severe side effects, reducing to 1.7 mg temporarily before returning to maintenance dosing may help

NSAIDs should be used cautiously in patients with renal impairment, cardiovascular disease, or gastrointestinal risk factors

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