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The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches

9 Conclusion The favorable impacts of omega-3 PUFAs on the neurovascular microenvironment indicate their potential to influence neural and immune cells in the brain through various physical and biochemical pathways, leading to outcomes such as anti-inflammatory, anti-nociceptive, antioxidative, and mood regulation

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This minimizes waste from the 28-day use window