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Due to its mechanism of action involving multiple hormones, Zepbound may help patients achieve even more significant weight loss than Wegovy

The FDA label for Zepbound does not list hormonal interaction as a mechanism

Front Psychiatry 13:1092828 Tyler RE, Bluitt MN, Van Voorhies K et al (2022) Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats

Without additional long-term studies, researchers cannot ascertain whether humans face a similar risk

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