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Because biological APIs are inherently labile, these stresses and environmental transitions introduce the risk of conformational change, aggregation between API molecules or API and excipient(s), and precipitation
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References Adams, T
In previous I/R models, these effects include attenuation of oxidative stress, preservation of endothelial and microvascular integrity, modulation of nitric oxide signaling, suppression of inflammatory cytokine expression, and regulation of apoptotic pathways.55,62,63 These properties suggest that BPC 157 may represent a potential therapeutic candidate for I/R injury
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