For example, certain antidepressants, antipsychotics, and corticosteroids may cause weight gain as a side effect
Beyond weight loss, these medications improve multiple metabolic parameters including hemoglobin A1c, blood pressure, and lipid profiles
Although all unimolecular triple agonists in phase 2 trials for obesity are GLP1/GIP/GCG triple agonists, there is an ongoing phase 2 clinical trial of bioglutide, an oral insulin-like-growth factor-1 (IGF-1)/GLP-1/GIP/GCG quadruple agonist (NCT06564753) for individuals with obesity, which is also being trialled in combination with tirzepatide (NCT06643728)
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If you take too much Rybelsus, contact your healthcare provider immediately
Overall, although guidelines and regulatory bodies appear to endorse a weight loss of 5% as clinically meaningful, the rigour with which this number was arrived at is unclear
