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Miller DH, Leary SM

Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects

Regulatory T Cells (Tregs): GPX4-maintained redox balance is essential for regulatory T cell (Treg) function, as its deficiency disrupts immune homeostasis through lipid peroxidation-mediated impairment, potentially driving pathogenesis in autoimmune diseases like SLE and RA (73)

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