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These coepidemic conditions result in a huge patient population that can be reached, with around 85-90% of the type 2 diabetes cases being attributed to excess body weight/central adiposity

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The TMAO precursor and rate-limiting synthesis factor, trimethylamine (TMA), is produced by the gut microbiome from dietary choline, phosphatidylcholine, betaine and L-carnitine [18, 19]

We know that adequate levels of selenium have been associated with a reduction in TPO antibody levels

Patients with pre-existing cardiovascular disease, uncontrolled hypertension, or significant cardiac risk factors require particularly careful assessment

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