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As the skin permeability barrier is often impaired in rosacea, causing additional skin sensitivity and irritation [8], metronidazole 7.5 mg/g cream twice daily was applied throughout the courses of treatment, based on its proven effects in reducing skin irritation, transepidermal water loss, and erythema [12]

[DOI] [PMC free article] [PubMed] [Google Scholar] Gao XH, Krokowski D, Guan BJ, Bederman I, Majumder M, Parisien M, Diatchenko L, Kabil O, Willard B, Banerjee R, et al

2005 Jun;52(3):337-43

This applies to TRT injections for men and topical hormone therapy for women and does not apply to pellet therapy

Correction of a glutathione deficiency in the ageing mosquito increases its longevity

M., Wu, J., Mon-Williams, M., Phillips, N