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Some studies have found increased permeability or leakiness in both the small and large intestines of IBS patients compared to healthy people, however others have found no significant differences.(1, 2) Part of the challenge for researchers is that current methods of measuring or diagnosing intestinal barrier dysfunction are suboptimal and more reliable tests need to be developed.(6) IBS patients have no obvious signs of inflammation when their gut is examined under a microscope, so the clinical significance of leakiness or defects in the gut barrier needs to be addressed by future research.(1, 2) The short answer, no, not that we know of

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A physician-directed topical protocol typically follows a progression

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