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Type 2 diabetes is driven by insulin resistance and pancreatic cell dysfunction
Brzozowski T, Konturek PC, Pajdo R, et al
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Diabetes is characterized by chronic systemic hyperglycemia, which activates several secondary metabolic pathwayssuch as the polyol pathway, accumulation of AGE products, and protein kinase C (PKC) activationthat contribute to retinal and systemic vascular damage [67]
As an endogenous regulatory peptide, DSIP functions as a neuromodulator within central nervous system signaling pathways, where it is studied as a modulator of hypothalamic and circadian rhythmassociated processes
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