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The normally distributed continuous variables were analyzed by T -test and the skewed variables were analyzed by MannWhitney U -test

This is the same mechanism used by the bodys own GHRH, which means sermorelin: Preserves the natural pulsatile pattern of GH release Maintains somatostatin feedback inhibition Supports long-term pituitary function rather than suppressing it Works synergistically with exercise and sleep, which naturally enhance GHRH signaling Clinical History Sermorelin has a notable clinical history

doi: 10.3390/jcm8060796 145 LiuDLiXZhangYKwongJSLiLZhangYet al

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In preclinical studies, Ipamorelin has demonstrated minimal effects on cortisol, prolactin, and aldosterone levels at GH-stimulating concentrations, making it a cleaner research tool for isolating GH-specific effects