Aconitase is highly sensitive to inactivation by superoxide because of its labile iron atom and its proximity to the superoxide-generating electron transport chain
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These cross-niche enrichment patterns, together with significant oral community separation but non-significant gut beta-diversity separation by ANOSIM, were accompanied by predicted decrements in 85 orally enriched enzymes distributed across 25 KEGG pathways, approximately 40 % of which were associated with the biosynthesis of metabolites with reported neuroprotective properties, including glutathione, acetyl-CoA, succinate, malate, formate, lactate, acetate, and monoterpenoids
6c) demonstrated that the predicted motif containing two P-Thr fits exactly to the region of the unassigned cryo-EM density (CCC = 0.85 at 4 map resolution for the AF3 prediction of SNIP1 FHA domain in complex with the SF3B1 phospho-peptide) (Fig