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If you find yourself wanting to switch after every minor plateau or side effect flare, it may be worth exploring whether the desire to alternate reflects a reasonable medical strategy or an anxious response to normal treatment fluctuations

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showed that rifaximin changed the bacterial population in the ileum of rats, increasing the relative abundance of Lactobacillus, and preventing mucosal inflammation and impaired intestinal barrier [156]

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If that window has passed, it should be skipped rather than doubled

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