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In women with PMOS, kisspeptin signalling is dysregulated

The mechanism appears to be loss of L-carnitine through the kidneys

Individuals who are pregnant, breastfeeding, or have a history of pancreatitis, kidney failure, gallbladder disease, medullary thyroid carcinoma, MEN2 syndrome, or eating disorders should not use GLP-1 medications regardless of dose

Liraglutide binds to GLP-1Rs expressed in ARC POMC neurons, thereby activating them [2]

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This process relies on proper hydration and the ability of your vascular system to deliver oxygen-rich blood efficiently