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Because TB-500 distributes systemically regardless of injection site, there is no clinical requirement to inject near the injury

With overuse, there is documented concern around kidney stress

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359 Side-sleeping appears to promote better cleansing of brain tissue through increased glymphatic drainage

2021]Long-term survival with sebelipase alfa enzyme replacement therapy in infants with rapidly progressive lysosomal acid lipase deficiency: final results from 2 open-label studies