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This is the molecular basis of the long known observation that the oxidative damage plays an important role in hepatic fibrogenesis.5 Non-alcoholic steatohepatitis (NASH), aging and oxidative stress NASH is a liver disease characterized by histopathological features similar to those of alcoholic liver disease occurring in the absence of significant alcohol consumption.34 It has been proposed that the oxidative stress may be generated by the accumulation of free fatty acids in mitochondria, saturation of mitochondrial -oxidation and excess H2O2 production during peroxisomal -oxidation and to CYP2E1 induction

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10.1371/journal.pone.0161208 45 RebiereH.GuinotP.ChauveyD.BrenierCh

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